A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens
نویسندگان
چکیده
منابع مشابه
A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens.
BACKGROUND The hygiene hypothesis negatively correlates the microbial burden of the environment with the prevalence of T helper type 2 (Th2)-related disorders, e.g. allergy and asthma. This is explained by Th1 triggering through pathogen-associated molecular patterns via Toll-like receptors (TLRs). In this study, the biological effects of a TLR2/6 agonist as a potential treatment of allergic in...
متن کاملA Toll - like receptor 2 / 6 - agonist reduces allergic airway inflammation in chronic respiratory 1 sensitisation to
30 Background: The hygiene hypothesis negatively correlates the microbial burden of the 31 environment to the prevalence of Th2-related disorders, e.g. allergy and asthma. This is 32 explained by Th1-triggering through pathogen-associated molecular patterns via toll-like 33 receptors. In this study, biological effects of a potential use of toll-like receptor (TLR) 2/6 34 agonists for treatment ...
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The initial dose should be administered under the supervision of a physician because anaphylaxis and laryngopharyngeal edema have occurred in rare cases.1 The manufacturer suggests that timothy grass pollen allergen extract be avoided in patients taking beta blockers, alpha blockers, ergot alkaloids, tricyclic antidepressants, levothyroxine, monoamine oxidase inhibitors, chlorpheniramine, diphe...
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In a mouse experimental asthma model, the administration of bacterial lipopolysaccharide (LPS), particularly at low doses, enhances the levels of ovalbumin (OVA)-induced eosinophilic airway inflammation. In an effort to clarify the cellular and molecular basis for the LPS effect, we demonstrate that the OVA-induced eosinophilic inflammation in the lung is dramatically increased by the administr...
متن کاملSensitization to timothy grass pollen allergenic molecules in children
BACKGROUND Grass pollens are significant elicitors of IgE-mediated allergic disease in the world and timothy (Phleum pratense) is one of the most important pollens of the family. Molecular and biochemical characterization of Phleum pratense has revealed several allergen components: rPhl p 1 and rPhl p 5 have been shown to be "Species Specific Allergens", while the profilin rPhl p 12 and the cal...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 2010
ISSN: 1423-0097,1018-2438
DOI: 10.1159/000265534